For over 20 years Street Fighter 2 stood as Capcom’s highest selling game in the history of the company. That is no longer the case however, over on Capcom’s Investor relations site—Resident Evil 5 has now been pegged as the highest selling game in the history of the company to date.
Kind of surprised a Monster Hunter game isn’t at the top honestly, considering that franchise is monstrous in Japan. Although the Resident Evil brand does have a lot more global appeal.
[Source]